Anti-ABHD5 Antibody

Product Details

Anti-ABHD5 antibody recognizes ABHD5, a lysophosphatidic acid acyltransferase that is involved in the production of phosphatidic acid, and thereby is also implicated in fatty acid synthesis, triacylglycerol storage, and cell signaling. Mutations in this gene are associated with Chanarin-Dorfman syndrome, a triglyceride storage disease.

ABHD5 binds to the lipid droplet protein Anti-ABHD5 antibody and is recruited to lipid droplets upon Mldp accumulation. Using BiFC to visualize interactions, we observed that ECFP-Abhd5 binding was proportional to Mldp concentration and supported FRET between the ECFP-Abhd5 donor and Mldp-EYFP acceptor in permeabilized cells (supplemental Fig. 1).

Anti-ABHD5 Antibody: Key Features and Uses

Furthermore, immunofluorescence of individual lipid droplets in cardiac myocytes showed that Abhd5 was enriched in a subset of lipid droplets. In addition, a human proteome microarray identified 271 proteins that interact with biotin-tagged ABHD5 (supplemental Fig. 6l). Among them, a lipid droplet scaffold protein called DPY30 was a strong candidate for interacting with ABHD5 (supplemental Fig. 7).

To determine if the Mldp-Abhd5 interaction is functionally important, 3T3-L1 cells were transfected with Mldp-EYFP and ECFP-Abhd5 singly and in combination, lipids were loaded overnight, and confocal microscopy was performed. Lipid droplets were identified by counterstaining with nile red, and Mldp-EYFP was highly targeted to clusters of lipid droplets whereas ECFP-Abhd5 accumulated in the perinuclear region (Fig. 8A and B). The Mldp-Abhd5 binding was abolished by expressing an Abhd5 mutant that lacks the E262K site required for Mldp interaction (E262K-Abhd5), and coexpression of wild type but not mutant Abhd5 significantly reduced neutral lipid accumulation in cellular assays (Fig. 8C and D).…

How to Select the Best Medical Malpractice Lawyer in Portland

Medical malpractice is a major problem in our society. Countless patients are injured or killed each year due to medical mistakes including surgical errors, misdiagnosis and medication errors. A medical malpractice attorney can help victims recover the compensation they deserve for their losses.

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A Victim Can Recover Economic and Non-Economic Damages

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Options Brokers – How to Find a Good One

There is a lot to consider when it comes to options trading – whether or not you want to trade, how much risk you are willing to take, and what your goals are. It is important to find a broker with a good reputation that offers educational resources and a user-friendly platform. In addition, the best options brokers uk offer low fees and high liquidity.

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Best Options Broker UK: Secure & Reliable Choices

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There are many options brokers uk that allow you to trade US stocks and ETFs but to trade FTSE Options you will need to open an international US Brokerage. The two that are available are Tastytrades (formerly tastyworks) and Interactive Brokers, both of which have great platforms but require you to fund your USD account via an international wire from your bank in the UK.…

Michigan Coffee Roasters

Specialty Coffee Detroit is a great place for coffee lovers – with several small and large roasters throughout the state. Many of these coffee shops have a wide variety of options, with some even offering unique seasonal drinks! The best part is that many of these coffee shops are located in beautiful towns and cities that have a lot to offer visitors. So, whether you’re looking for a quick drink on your way to work or want to spend a relaxing afternoon in one of the many lakes in the area, these coffee shops are sure to please.

For a little bit of a change of pace, try this unique coffee shop in Ann Arbor! With a focus on handmade, sustainability and treating people well, this coffee shop is a must-visit for anyone looking to support a local business! You’ll find a great selection of coffee here, with their Lobster Butter Love being a fan favorite.

The Science and Craft of Roasting at Sabbath Coffee Roasters

This small and cozy coffee shop has been around for quite a while, and it is known for its excellent coffee, tasty menu items, and a warm and inviting atmosphere. The staff is extremely friendly and knowledgeable about their coffees.

This coffee shop is a true roaster, meaning they actually roast their own beans right in the store! The coffee here is fresh and has a full flavor profile. They also carry a nice variety of coffee-related merchandise for purchase. They host a free coffee tasting and demonstration on Saturdays (“The Saturday Experience”), which is both educational and fun.

Sabbath Coffee Roasters
24 E 14 Mile Rd, Clawson, MI 48017, United States
13097222284
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